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Staging Colorectal Cancer

Colorectal cancer can grow outside of the colon or rectum. In time, it can grow into nearby organs or spread to nearby lymph nodes (immune system tissues) and then travel to other parts of the body. Cancer cells can also get into the blood to travel to other parts of the body. This is called metastasis. 

Doctors stage cancer to tell how much cancer there is, whether it has spread, and if so, how far. Staging may be done before or after surgery. Knowing the cancer stage helps healthcare providers make the best treatment plan for each person.

Colorectal cancer has 5 stages. They're numbered 0 through 4 using Roman numerals (0, I, II, III, and IV). Colorectal cancer tends to start in the inside lining and then moves deeper into the colon wall. If cancer is found early, when it's only in the inside lining (the mucosa), it may be called stage 0 or carcinoma in situ. The other stages are:

Stage I: Cancer has spread through the inner layer (mucosa). It may be deeper in the middle lining layers (submucosa) or in the muscle layers of the colon or rectum.

Cross section of colon and lymph nodes, showing cancer inside colon.

Stage II: Cancer has spread through the muscle layer and may be through the outer wall (serosa) of the colon or rectum. It may have spread to nearby organs or tissues. Cancer has not spread to lymph nodes or distant parts of the body.

Cross section of colon and lymph nodes showing cancer spreading through wall of colon but not to lymph nodes.

Stage III: Cancer may or may not have spread through the wall of the colon or rectum. It has spread to nearby lymph nodes and/or into the fat around them. It may have spread to nearby tissues or organs. It has not spread to other parts of the body.

Cross section of colon and lymph nodes showing cancer spreading through wall of colon and to lymph nodes.

Stage IV: Cancer has spread to distant parts of the lining of the abdomen (called the peritoneum) and/or to distant lymph nodes or organs, like the lungs and liver.

Outline of body showing digestive and respiratory tracts, with arrows showing spread of cancer.

Online Medical Reviewer: Kimberly Stump-Sutliff RN MSN AOCNS
Online Medical Reviewer: Louise Cunningham RN BSN
Online Medical Reviewer: Richard LoCicero MD
Date Last Reviewed: 12/1/2021
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